Amine N-methyltransferase

Amine N-methyltransferase is an enzyme that catalyzes the N-methylation reaction of amine compounds. According to the substrates of Amine N-methyltransferase, it can be classified into PNMT, NNMT, GNMT and HNMT. Amine N-methyltransferase is involved in physiological processes such as neurotransmitter metabolism and bioactive natural products synthesis. Changes in the activity of amine Amine N-methyltransferase are related to the occurrence and development of diseases such as neurological diseases and cancers^[1].

References:

[1]. Ansher SS, et al. Amine N-methyltransferases. Methods Enzymol. 1987;142:660-7. [Content Brief]

Amine N-methyltransferase Inhibitors (5)

Amine N-methyltransferase Related Products (5):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-151500B

JBSNF-000028 hydrochloride	Inhibitor
JBSNF-000028 hydrochloride is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC₅₀s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 hydrochloride can be used for the research of metabolic disorders.

HY-151500A

JBSNF-000028 TFA	Inhibitor	99.47%
JBSNF-000028 TFA is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC₅₀s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 TFA can be used for the research of metabolic disorders.

HY-151500

JBSNF-000028 free base	Inhibitor	99.20%
JBSNF-000028 is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC₅₀s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 can be used for the research of metabolic disorders.

HY-163174

II399	Inhibitor
II399 is a potent, selective NNMT bisubstrate inhibitor containing an unconventional SAM mimic, with a K_i of 5.9 nM. II399 exhibits an explicit pattern of competitive inhibition for NAM. II399 occupies both the substrate and cofactor binding pockets. II399 has the potential for the research of cancers, metabolic, cardiovascular, and neurodegenerative diseases.

HY-W093017

4-Chloropyridine	Inhibitor
4-Chloropyridine is an inhibitor of nicotinamide N-methyltransferase (NNMT). It can act as a substrate for NNMT and, during its catalytic reaction, enhances the electrophilicity of the C4 position by methylating the nitrogen atom of the pyridine ring. This promotes an aromatic nucleophilic substitution reaction with the non-catalytic cysteine (C159) in NNMT, ultimately leading to the suicide inhibition of NNMT's activity. 4-Chloropyridine holds potential for the development of NNMT activity-based probes .

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